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Canniboids and your health


“Cannabinoids” is a blanket term covering a family of complex chemicals (both natural and man-made) that lock on to cannabinoid receptors – protein molecules on the surface of cells.

Humans have been using cannabis plants for medicinal and recreational purposes for thousands of years, but cannabinoids themselves were first purified from cannabis plants in the 1940s. The structure of the main active ingredient of cannabis plants – delta-9 tetrahydrocannabinol (THC) – was discovered in the 60s. It wasn’t until the late 1980s that researchers found the first cannabinoid receptor, followed shortly by the discovery that we create cannabinoid-like chemicals within our own bodies, known as endocannabinoids.

We have two different types of cannabinoid receptor, CB1 and CB2, which are found in different locations and do different things. CB1 is mostly found on cells in the nervous system, including certain areas of the brain and the ends of nerves throughout the body, while CB2 receptors are mostly found in cells from the immune system. Because of their location in the brain, it’s thought that CB1 receptors are responsible for the infamous ‘high’ (known as psychoactive effects) resulting from using cannabis.

Over the past couple of decades scientists have found that endocannabinoids and cannabinoid receptors are involved in a vast array of functions in our bodies, including helping to control brain and nerve activity (including memory and pain), energy metabolism, heart function, the immune system and even reproduction. Because of this molecular multitasking, they’re implicated in a huge range of illnesses, from cancer to neurodegenerative diseases.

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There is no doubt that cannabinoids – both natural and synthetic – are interesting biological molecules. Hundreds of scientists around the world are investigating their potential in cancer and other diseases – as well as the harms they can cause – brought together under the blanket organisation The International Cannabinoid Research Society.

Researchers first looked at the anticancer properties of cannabinoids back in the 1970s, andmany hundreds of scientific papers looking at cannabinoids and cancer have been published since then. This Wellcome Witness seminar is also fascinating reading for aficionados of the history of medical cannabis, including the scientific, political and legal twists. [Updated KA 26/03/14]


Cannabis sativa L. preparations have been used in medicine for millenia. However, concern over the dangers of abuse led to the banning of the medicinal use of marijuana in most countries in the 1930s. Only recently, marijuana and individual natural and synthetic cannabinoid receptor agonists and antagonists, as well as chemically related compounds, whose mechanism of action is still obscure, have come back to being considered of therapeutic value. However, their use is highly restricted. Despite the mild addiction to cannabis and the possible enhancement of addiction to other substances of abuse, when combined with cannabis, the therapeutic value of cannabinoids is too high to be put aside. Numerous diseases, such as anorexia, emesis, pain, inflammation, multiple sclerosis, neurodegenerative disorders (Parkinson's disease, Huntington's disease, Tourette's syndrome, Alzheimer's disease), epilepsy, glaucoma, osteoporosis, schizophrenia, cardiovascular disorders, cancer, obesity, and metabolic syndrome-related disorders, to name just a few, are being treated or have the potential to be treated by cannabinoid agonists/antagonists/cannabinoid-related compounds. In view of the very low toxicity and the generally benign side effects of this group of compounds, neglecting or denying their clinical potential is unacceptable - instead, we need to work on the development of more selective cannabinoid receptor agonists/antagonists and related compounds, as well as on novel drugs of this family with better selectivity, distribution patterns, and pharmacokinetics, and - in cases where it is impossible to separate the desired clinical action and the psychoactivity - just to monitor these side effects carefully.


With more studies, fewer regulations and increased acceptance, CBD hemp oil is gaining in popularity – with good reason. Shown to decrease seizures, alleviate anxiety, reduce inflammation and help with PTSD symptoms, CBD hemp oil is attracting entrepreneurs who want to make a quick buck on the heady crop. These capitalists tend to source their hemp from less-than-organic farms, use cheaper petroleum-based extraction methods, and provide no lab results or testing of their product to ensure potency. This makes it difficult for the consumer to decide what is high quality CBD oil and what isn’t.


The chemical compounds found in the Cannabis plant, called cannabinoids, offer a variety of health benefits. While there are over 80 different cannabinoids in marijuana, only a handful have been researched and are known to provide positive effects on the human body. Understanding how cannabinoids affect the body helps you find the right strain for your individual needs.

Tetrahydrocannabinol, or THC, is the most well-known cannabinoid due to its euphoric and psychoactive effects on your body (i.e.; the "high"). THC can alter behavior, consciousness, mood and perception. Marijuana is often prescribed as a pain killer -- one of the main health benefits of THC. THC is commonly used to stimulate your appetite.

THC-A is the acidic form of THC known as tetrahydrocannabinolic acid. THC-A is the biosynthetic precursor for THC without any psychoactive effects. A variety of pharmacological effects are associated with THC-A, including anti-inflammatory, antiemetic, anti-prostate cancer, anti-vomiting and neuroprotective. Purified THC-A forms an unstable powder.

Tetrahydrocannabivarin, or THC-V, is a homologue of THC found naturally in the Cannabis plant. THC-V has a propyl side chain group on the molecule which can affect your body much differently than THC. This cannabinoid is often associated with appetite suppression, reduced blood sugar and bone growth stimulation.

Cannabinol, abbreviated as CBN, stems from cannabigerolic acid. CBN is the cannabinoid responsible for inducing sedative-like effects. You might want to reserve strains with high levels of CBN for use before bed. CBN is also used as an anti-bacterial and may reduce muscle spasms.

Most health benefits of marijuana are associated with the cannabidiol cannabinoid, known as CBD. Marijuana products are often enhanced with CBD to provide more potent effects. Choose a strain with high levels of CBD if you're looking to use marijuana as an alternative form of medication. CBD is also used to treat Dravet syndrome, sold under the drug brand name of Epidiolex.

Some other common cannabinoids include CBD-A, CBC, CBC-A, CBG and CBG-A. Use the "Health Effects of Marijuana" chart, below, to identify which cannabinoids induce the effects you're looking for.

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This documentary is about Marijuana and cancer.
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I watched a CNN (I know) series with Sanjay Gupta on cannabanoids for a class. Insightful! Appears to have some real medical benefits with minimal side-effects for some patients.

More good data for the reference banks Yeah3
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Commented not too long ago about how CBD oil.has helped a bunch with a chronic pain issue. Don't have to take opioid pain drugs much at all anymore. Still have some really shitty days that demand the stronger pain management stuff, but not that often anymore. And if it is a placebo effect, all good with that too. Let my brain trick me. Whatever works.
"Why don't you just speak with your words instead of your damn dirty lies?"
~Louise Belcher.
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I don't really use it anymore.
But I am all for this sacred medicine.
It is a gift from God and should be treated as such. Heartflowers

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"It's All Going to Pot" Willie Nelson & Merle Haggard


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I have chronic migraine and LOVE it.
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(10-11-2017, 11:41 AM)EyesWideOpen111 Wrote:
"It's All Going to Pot" Willie Nelson & Merle Haggard


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